{"id":10109,"date":"2025-09-20T13:30:16","date_gmt":"2025-09-20T06:30:16","guid":{"rendered":"https:\/\/huanqiuribao.com\/?p=10109"},"modified":"2025-09-20T09:52:47","modified_gmt":"2025-09-20T02:52:47","slug":"%e5%8f%a3%e6%9c%8d%e7%89%88%e5%87%8f%e8%82%a5%e7%a5%9e%e8%8d%af%e5%8d%b3%e5%b0%86%e9%97%ae%e4%b8%96","status":"publish","type":"post","link":"https:\/\/huanqiuribao.com\/?p=10109","title":{"rendered":"\u53e3\u670d\u7248\u201c\u51cf\u80a5\u795e\u836f\u201d\u5373\u5c06\u95ee\u4e16"},"content":{"rendered":"

\u25b3\u8bfa\u548c\u8bfa\u5fb7\u7684GLP-1\u51cf\u80a5\u836f\u7247\uff0c\u76ee\u524d\u5c1a\u672a\u5728\u4efb\u4f55\u5730\u533a\u83b7\u51c6\u4f7f\u7528\u3002\u56fe\u7247\u6765\u6e90\uff1aNOVO NORDISK<\/p>\n

\u4e9a\u7279\u5170\u5927\u5730\u533a\u7684\u80a5\u80d6\u75c7\u533b\u5b66\u4e13\u5bb6\u3001\u7f8e\u56fd\u4e34\u5e8a\u5185\u5206\u6ccc\u5b66\u534f\u4f1a(American Association of Clinical Endocrinology)\u4f1a\u957f\u65af\u79d1\u7279\u30fb\u827e\u8428\u514b\u65af(Scott Isaacs)\u535a\u58eb\u8bf4\uff1a\u201c\u8bb8\u591a\u60a3\u8005\u5c1d\u8bd5\u8fc7\u4e0d\u540c\u7684\u836f\u7269\uff0c\u4f46\u8981\u4e48\u5bf9\u4ed6\u4eec\u65e0\u6548\uff0c\u8981\u4e48\u6709\u526f\u4f5c\u7528\uff0c\u4ed6\u4eec\u60f3\u5c1d\u8bd5\u4e00\u4e9b\u65b0\u4e1c\u897f\u3002\u201d\u4ed6\u79f0\uff1a\u201c\u6211\u8ba4\u4e3a\uff0c\u591a\u4e00\u4e2a\u53ef\u4f9b\u8f6c\u6362\u7684\u9009\u62e9\uff0c\u5bf9\u5f88\u591a\u4eba\u6765\u8bf4\u90fd\u4f1a\u6709\u5438\u5f15\u529b\u3002\u201d<\/p>\n

\u8bfa\u548c\u8bfa\u5fb7(Novo Nordisk)\u7684\u53f8\u7f8e\u683c\u9c81\u80bd(semaglutide)\u53e3\u670d\u836f\u6709\u671b\u6210\u4e3a\u9996\u6b3e\u4e13\u95e8\u83b7\u6279\u7528\u4e8e\u51cf\u80a5\u7684GLP-1\u53e3\u670d\u836f\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u662fWegovy\u548c\u7cd6\u5c3f\u75c5\u6cbb\u7597\u836f\u7269\u8bfa\u548c\u6cf0(Ozempic)\u7684\u4e3b\u8981\u6210\u5206\u3002\u8be5\u516c\u53f8\u5df2\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40(U.S. Food and Drug Administration, \u7b80\u79f0FDA)\u63d0\u4ea4\u7533\u8bf7\uff0c\u9884\u8ba1\u5ba1\u6279\u51b3\u5b9a\u5c06\u5728\u5e74\u5e95\u524d\u505a\u51fa\uff0c\u4ece\u800c\u4f7f\u8be5\u836f\u53ef\u80fd\u57282026\u5e74\u521d\u4e0a\u5e02\u3002<\/p>\n

\u793c\u6765\u516c\u53f8(Eli Lilly)\u7684\u540c\u7c7b\u4ea7\u54c1\u542b\u6709\u4e00\u79cd\u65b0\u7684\u4e3b\u8981\u6210\u5206orforglipron\uff0c\u4f5c\u7528\u65b9\u5f0f\u4e0d\u540c\u4e8e\u5176\u6ce8\u5c04\u5242Zepbound\u7684\u4e3b\u8981\u6210\u5206\u66ff\u5c14\u6cca\u80bd(tirzepatide)\u3002Orforglipron\u662f\u4e00\u79cdGLP-1\u836f\u7269\uff0c\u53ef\u6a21\u62df\u4e00\u79cd\u80a0\u9053\u6fc0\u7d20\u6765\u5e2e\u52a9\u6291\u5236\u98df\u6b32\u3002\u4f46\u5b83\u4e0d\u50cfZepbound\u90a3\u6837\u540c\u65f6\u6a21\u62df\u7b2c\u4e8c\u79cd\u80a0\u9053\u6fc0\u7d20\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u7814\u7a76\u8868\u660e\u5b83\u7684\u6548\u679c\u4e0d\u5982\u6ce8\u5c04\u5242\u3002\u8be5\u516c\u53f8\u8ba1\u5212\u5728\u4eca\u5e74\u5e74\u5e95\u524d\u5411FDA\u7533\u8bf7\u6279\u51c6\u8be5\u836f\uff0c\u4ece\u800c\u53ef\u80fd\u57282026\u5e74\u7684\u67d0\u4e2a\u65f6\u5019\u4e0a\u5e02\u3002<\/p>\n

\u5305\u62ec\u963f\u65af\u5229\u5eb7(AstraZeneca)\u548cStructure Therapeutics\u5728\u5185\u7684\u5176\u4ed6\u516c\u53f8\u4e5f\u5728\u5f00\u53d1\u6b64\u7c7b\u53e3\u670d\u836f\uff0c\u5982\u679c\u6d4b\u8bd5\u6210\u529f\uff0c\u53ef\u80fd\u4f1a\u5728\u51e0\u5e74\u540e\u4e0a\u5e02\u3002<\/p>\n

\u4e0e\u6ce8\u5c04\u5242\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u65b0\u53e3\u670d\u836f\u53ef\u80fd\u9700\u8981\u6743\u8861\u5229\u5f0a\u3002\u7814\u7a76\u663e\u793a\uff0c\u670d\u7528\u53e3\u670d\u836f\u53ef\u80fd\u51cf\u91cd\u6548\u679c\u4e0d\u4f73\u3002\u800c\u4e14\u4e0e\u6ce8\u5c04\u5242\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u53e3\u670d\u836f\u53ef\u80fd\u4f1a\u5728\u66f4\u591a\u60a3\u8005\u4e2d\u5f15\u8d77\u6076\u5fc3\u7b49\u80a0\u80c3\u76f8\u5173\u526f\u4f5c\u7528\u3002\u533b\u751f\u548c\u5206\u6790\u5e08\u8868\u793a\uff0c\u8fd9\u4e9b\u53e3\u670d\u836f\u53ef\u80fd\u66f4\u9002\u5408\u9700\u8981\u51cf\u53bb\u8f83\u5c11\u4f53\u91cd\u7684\u4eba\uff0c\u800c\u91cd\u5ea6\u80a5\u80d6\u8005\u53ef\u80fd\u9700\u8981\u575a\u6301\u4f7f\u7528\u6ce8\u5c04\u5242\u3002<\/p>\n

\u5373\u4f7f\u5b58\u5728\u5c40\u9650\u6027\uff0cGLP-1\u51cf\u80a5\u53e3\u670d\u836f\u7684\u5e02\u573a\u4e5f\u53ef\u80fd\u975e\u5e38\u5e9e\u5927\u3002Leerink Partners\u4e13\u6ce8\u4e8e\u533b\u7597\u5065\u5eb7\u6295\u8d44\u94f6\u884c\u4e1a\u52a1\uff0c\u8be5\u673a\u6784\u5206\u6790\u5e08\u5927\u536b\u30fb\u8d56\u8f9b\u683c(David Risinger)\u4f30\u8ba1\uff0c\u8fd9\u7c7b\u53e3\u670d\u836f\u6700\u7ec8\u53ef\u80fd\u5360\u636e\u6574\u4e2a\u5e02\u573a\u7ea625%\u7684\u4efd\u989d\u3002\u8d56\u8f9b\u683c\u8bf4\uff1a\u201c\u5b83\u4eec\u4ecd\u6709\u6f5c\u529b\u521b\u9020\u5de8\u989d\u9500\u552e\u989d\uff0c\u56e0\u4e3a\u6d88\u8d39\u8005\u5bf9\u53e3\u670d\u51cf\u80a5\u836f\u7684\u9700\u6c42\u5c06\u662f\u5de8\u5927\u7684\u3002\u201d<\/p>\n

\u636e\u5206\u6790\u516c\u53f8TD Cowen\u79f0\uff0c\u76ee\u524d\u8fd9\u6279\u6ce8\u5c04\u836f\u7269\uff08\u5305\u62ec\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff09\u9884\u8ba1\u4eca\u5e74\u5c06\u5728\u5168\u7403\u4ea7\u751f\u7ea6720\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002<\/p>\n

TD Cowen\u7684\u5206\u6790\u5e08\u8fc8\u514b\u5c14\u30fb\u5185\u5fb7\u5c14\u79d1\u7ef4\u5947(Michael Nedelcovych)\u8868\u793a\uff0c\u8fd9\u4e9b\u516c\u53f8\u53ef\u80fd\u5fc5\u987b\u514b\u670d\u533b\u751f\u7684\u6000\u7591\u6001\u5ea6\u3002\u4ed6\u7684\u8c03\u67e5\u663e\u793a\uff0c\u533b\u751f\u666e\u904d\u8ba4\u4e3a\u6ce8\u5c04\u836f\u7269\u66f4\u6709\u6548\uff0c\u5e76\u4e14\u6ca1\u6709\u770b\u5230\u60a3\u8005\u5bf9\u53e3\u670d\u836f\u6709\u8feb\u5207\u9700\u6c42\u3002\u4f46\u4ed6\u8868\u793a\uff0c\u5982\u679c\u53e3\u670d\u836f\u5b9a\u4ef7\u8f83\u4f4e\uff0c\u4fdd\u9669\u8986\u76d6\u8303\u56f4\u53ef\u80fd\u4f1a\u66f4\u597d\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u9500\u552e\u3002<\/p>\n

\u8fd9\u4e9b\u6ce8\u5c04\u5242\u7684\u6807\u4ef7\u6bcf\u6708\u8d85\u8fc71,000\u7f8e\u5143\uff0c\u6298\u6263\u540e\u7684\u73b0\u91d1\u4ef7\u683c\u7ea6\u4e3a\u6bcf\u6708500\u7f8e\u5143\u3002\u9ad8\u6602\u7684\u6210\u672c\u662f\u7f8e\u56fd\u8bb8\u591a\u4fdd\u9669\u8ba1\u5212\u4e0d\u8986\u76d6\u51cf\u80a5\u836f\u7684\u4e00\u5927\u539f\u56e0\u3002<\/p>\n

\u793c\u6765\u548c\u8bfa\u548c\u8bfa\u5fb7\u5c1a\u672a\u900f\u9732\u5176\u53e3\u670d\u836f\u7684\u5177\u4f53\u5b9a\u4ef7\u8ba1\u5212\uff0c\u4f46\u4e00\u4e9b\u5206\u6790\u5e08\u9884\u8ba1\u4ef7\u683c\u5c06\u4f4e\u4e8e\u6ce8\u5c04\u5242\u3002<\/p>\n

\u9886\u5148\u7684\u6bcf\u5468\u6ce8\u5c04\u836f\u7269\uff0c\u5373\u8bfa\u548c\u8bfa\u5fb7\u7684Wegovy\u548c\u793c\u6765\u516c\u53f8\u7684Zepbound\uff0c\u5728\u5e2e\u52a9\u4eba\u4eec\u663e\u8457\u51cf\u8f7b\u4f53\u91cd\u65b9\u9762\u6548\u679c\u660e\u663e\u3002\u4f7f\u7528Zepbound\u7684\u6700\u9ad8\u5242\u91cf\u8fdb\u884c\u4e00\u5e74\u591a\u7684\u6cbb\u7597\u540e\u53ef\u5e2e\u52a9\u4eba\u4eec\u5e73\u5747\u51cf\u6389\u8d85\u8fc722%\u7684\u4f53\u91cd\uff0cWegovy\u53ef\u5e2e\u52a9\u4eba\u4eec\u51cf\u6389\u7ea617%\u7684\u4f53\u91cd\u3002<\/p>\n

\u7136\u800c\uff0c\u5b83\u4eec\u7684\u5236\u9020\u5546\u4e00\u76f4\u96be\u4ee5\u751f\u4ea7\u8db3\u591f\u7684\u4ea7\u54c1\u6765\u6ee1\u8db3\u9700\u6c42\uff0c\u90e8\u5206\u539f\u56e0\u662f\u5236\u9020\u5305\u88c5\u5728\u81ea\u52a8\u6ce8\u5c04\u5668\u4e2d\u7684\u65e0\u83cc\u6ce8\u5c04\u836f\u7269\u8fd9\u9879\u590d\u6742\u4efb\u52a1\u7684\u4ea7\u80fd\u6709\u9650\u3002\u5236\u9020\u53e3\u670d\u836f\u5219\u4e0d\u90a3\u4e48\u590d\u6742\uff0c\u800c\u4e14\u5168\u7403\u6709\u66f4\u591a\u7684\u4ea7\u80fd\u3002\u6b64\u5916\uff0c\u53e3\u670d\u836f\u4e0d\u9700\u8981\u51b7\u94fe\u5206\u9500\u548c\u50a8\u5b58\uff0c\u800c\u6ce8\u5c04\u5242\u9700\u8981\u51b7\u85cf\u3002<\/p>\n

\u5236\u836f\u5546\u5c06\u53e3\u670d\u836f\u89c6\u4e3a\u8ba9\u66f4\u591a\u4eba\u83b7\u5f97GLP-1\u836f\u7269\u7684\u91cd\u8981\u9014\u5f84\u3002<\/p>\n

\u201c\u4f60\u5c06\u4ee5\u4e00\u79cd\u4e0e\u6ce8\u5c04\u578bGLP-1\u975e\u5e38\u76f8\u4f3c\u7684\u65b9\u5f0f\uff0c\u83b7\u5f97\u51cf\u80a5\u3001\u8840\u7cd6\u63a7\u5236\u4ee5\u53ca\u6240\u6709\u8fd9\u4e9b\u771f\u6b63\u91cd\u8981\u7684\u4e8b\u60c5\uff0c\u201d \u793c\u6765\u5fc3\u810f\u4ee3\u8c22\u5065\u5eb7\u90e8\u95e8\u603b\u88c1\u80af\u5185\u65af\u30fb\u5361\u65af\u7279(Kenneth Custer)\u8bf4\u3002\u201c\u4f46\u73b0\u5728\u4f60\u4ee5\u53e3\u670d\u836f\u7684\u5f62\u5f0f\u83b7\u5f97\u5b83\uff0c\u8fd9\u79cd\u5f62\u5f0f\u53ef\u4ee5\u771f\u6b63\u5927\u89c4\u6a21\u63a8\u5e7f\uff0c\u5e76\u4e14\u6613\u4e8e\u60a3\u8005\u4f7f\u7528\u3002\u201d<\/p>\n

\u8bfa\u548c\u8bfa\u5fb7\u5df2\u7ecf\u9500\u552e\u4e00\u79cd\u540d\u4e3aRybelsus\u7684\u53f8\u7f8e\u683c\u9c81\u80bd\u53e3\u670d\u836f\uff0c\u7528\u4e8e\u6cbb\u7597\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3002\u5176\u4e3a\u51cf\u80a5\u5f00\u53d1\u7684\u53f8\u7f8e\u683c\u9c81\u80bd\u53e3\u670d\u836f\u5242\u91cf\u66f4\u9ad8\u3002\u8bfa\u548c\u8bfa\u5fb7\u8868\u793a\uff0c\u5728\u4e00\u9879\u6d89\u53ca300\u591a\u4eba\u7684\u4e09\u671f\u7814\u7a76\u4e2d\uff0cWegovy\u7684\u53e3\u670d\u836f\u7248\u672c\u5728\u6cbb\u759764\u5468\u540e\u5e2e\u52a9\u4eba\u4eec\u51cf\u6389\u4e8616.6%\u7684\u4f53\u91cd\u3002\u4e00\u4e9b\u60a3\u8005\u51fa\u73b0\u4e86GLP-1\u836f\u7269\u5e38\u89c1\u7684\u80a0\u80c3\u526f\u4f5c\u7528\uff0c\u5982\u6076\u5fc3\u548c\u5455\u5410\u3002\u7ea67%\u7684\u60a3\u8005\u56e0\u526f\u4f5c\u7528\u800c\u505c\u6b62\u6cbb\u7597\u3002<\/p>\n

\u5206\u6790\u5e08\u6307\u51fa\uff0c\u8bfa\u548c\u8bfa\u5fb7\u65b0\u6b3e\u51cf\u80a5\u836f\u5728\u4ea7\u91cf\u4e0a\u53ef\u80fd\u53d7\u9650\uff0c\u56e0\u4e3a\u8be5\u516c\u53f8\u5fc5\u987b\u5728\u6bcf\u7247\u836f\u4e2d\u6ce8\u5165\u5927\u91cf\u4e3b\u8981\u6210\u5206\uff0c\u4ee5\u786e\u4fdd\u6bcf\u4e2a\u4eba\u901a\u8fc7\u53e3\u670d\u80fd\u5438\u6536\u8db3\u591f\u7684\u5242\u91cf\u3002\u8fd9\u662f\u56e0\u4e3a\uff0c\u4e0e\u6ce8\u5c04\u7528\u53f8\u7f8e\u683c\u9c81\u80bd\u4e00\u6837\uff0c\u8be5\u53e3\u670d\u836f\u7531\u80bd\u7ec4\u6210\uff0c\u80bd\u6bd4\u4f20\u7edf\u53e3\u670d\u836f\u6240\u7528\u7684\u5c0f\u5206\u5b50\u8981\u5927\u3002<\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u8be5\u53e3\u670d\u836f\u7684\u5927\u5c0f\u4e0eRybelsus\u76f8\u4f3c\uff0c\u56e0\u6b64\u8fd9\u4e2a\u95ee\u9898\u5bf9\u8bfa\u548c\u8bfa\u5fb7\u7684\u751f\u4ea7\u6765\u8bf4\u662f\u4e2a\u6311\u6218\uff0c\u5bf9\u60a3\u8005\u5219\u4e0d\u7136\u3002<\/p>\n

\u8bfa\u548c\u8bfa\u5fb7\u7684\u8fd9\u6b3e\u53e3\u670d\u836f\u8fd8\u5fc5\u987b\u7a7a\u8179\u670d\u7528\uff0c\u7136\u540e\u60a3\u8005\u9700\u8981\u7b49\u5f8530\u5206\u949f\u624d\u80fd\u8fdb\u98df\u3002\u4e00\u4e9b\u5206\u6790\u5e08\u8ba4\u4e3a\uff0c\u4e0e\u793c\u6765\u7684\u53e3\u670d\u836f\u76f8\u6bd4\uff0c\u8fd9\u662f\u4e00\u4e2a\u52a3\u52bf\uff0c\u540e\u8005\u6ca1\u6709\u8fd9\u6837\u7684\u9650\u5236\u3002<\/p>\n

\u8bfa\u548c\u8bfa\u5fb7\u9996\u5e2d\u79d1\u5b66\u5b98\u9a6c\u4e01\u30fb\u970d\u5c14\u65af\u7279\u30fb\u5170\u683c(Martin Holst Lange)\u8868\u793a\uff0c\u8be5\u516c\u53f8\u62e5\u6709\u5f3a\u5927\u7684\u751f\u4ea7\u8bbe\u5907\uff0c\u5df2\u4e3a\u4e00\u65e6\u83b7\u6279\u540e\u4ea7\u54c1\u5168\u9762\u63a8\u51fa\u505a\u597d\u51c6\u5907\u3002\u4ed6\u8ba4\u4e3a\uff0c\u7a7a\u8179\u670d\u836f\u7684\u8981\u6c42\u4e0d\u4f1a\u6210\u4e3a\u51cf\u80a5\u7248\u836f\u7269\u7684\u4e3b\u8981\u9650\u5236\uff0c\u5e76\u6307\u51fa\u8be5\u516c\u53f8Rybelsus\u53e3\u670d\u836f\u4e5f\u6709\u540c\u6837\u7684\u8981\u6c42\u3002<\/p>\n

\u8bfa\u548c\u8bfa\u5fb7\u672c\u6708\u5ba3\u5e03\u8ba1\u5212\u5728\u5168\u7403\u88c1\u5458\u7ea611%\u3002\u8be5\u516c\u53f8\u8868\u793a\uff0c\u5305\u62ec\u51cf\u80a5\u53e3\u670d\u836f\u5728\u5185\u7684\u4e3b\u8981\u9879\u76ee\u4ecd\u5728\u7ee7\u7eed\u3002<\/p>\n

\u793c\u6765\u91c7\u53d6\u4e86\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u4e0d\u540c\u7684\u65b9\u6cd5\u3002\u5176GLP-1\u53e3\u670d\u836f\u7684\u4e3b\u8981\u6210\u5206orforglipron\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\uff0c\u8fd9\u610f\u5473\u7740\u8fd9\u4e9b\u53e3\u670d\u836f\u53ef\u4ee5\u4ee5\u66f4\u4f20\u7edf\u7684\u65b9\u5f0f\u751f\u4ea7\u3002<\/p>\n

\u7136\u800c\uff0c\u5728\u7814\u7a76\u4e2d\uff0corforglipron\u7684\u51cf\u91cd\u6548\u679c\u4e0d\u53caZepbound\u6216Wegovy\u3002\u5728\u4e00\u9879\u6d89\u53ca\u8d85\u8fc73,100\u540d\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u7814\u7a76\u4e2d\uff0c\u670d\u7528\u6700\u9ad8\u5242\u91cforforglipron\u8d85\u8fc7\u4e00\u5e74\u7684\u4eba\u5e73\u5747\u51cf\u6389\u4e8612.4%\u7684\u4f53\u91cd\u3002<\/p>\n

\u53e6\u4e00\u4e2a\u62c5\u5fe7\u662f\uff0c\u670d\u7528\u6700\u9ad8\u5242\u91cforforglipron\u7684\u60a3\u8005\u4e2d\u7ea6\u670910%\u56e0\u6076\u5fc3\u548c\u5455\u5410\u7b49\u526f\u4f5c\u7528\u800c\u8f83\u65e9\u505c\u6b62\u6cbb\u7597\u3002<\/p>\n

\u4f46\u793c\u6765\u8868\u793a\uff0c\u4e0a\u8ff0\u7814\u7a76\u7ed3\u679c\u8db3\u4ee5\u4f7forforglipron\u6210\u4e3a\u6ce8\u5c04\u5242\u7684\u6709\u5438\u5f15\u529b\u66ff\u4ee3\u54c1\u3002\u8be5\u516c\u53f8\u9884\u8ba1orforglipron\u5c06\u6210\u4e3a\u8bb8\u591a\u8d85\u91cd\u4eba\u58eb\u53ef\u884c\u7684\u8d77\u59cb\u6cbb\u7597\u65b9\u6848\u3002\u793c\u6765\u8fd8\u5728\u7814\u7a76\u8ba9\u901a\u8fc7\u6ce8\u5c04\u836f\u7269\u51cf\u80a5\u7684\u60a3\u8005\u6539\u7528\u8be5\u516c\u53f8\u53e3\u670d\u836f\u6765\u4fdd\u6301\u4f53\u91cd\u7684\u53ef\u80fd\u6027\u3002\uff08\u534e\u5c14\u8857\u65e5\u62a5\u7f51 \uff09<\/p>\n

 <\/p>\n

\u514d\u8d23\u58f0\u660e\uff1a\u7b2c\u4e09\u65b9\u65b0\u95fb\uff08\u6216\u56fe\u7247\uff09\u4e3a\u5206\u4eab\/\u63f4\u5f15\/\u50a8\u5b58\u4fe1\u606f\uff0c\u5176\u5185\u5bb9\u5e76\u4e0d\u4ee3\u8868\u672c\u62a5\/\u672c\u7f51\u7acb\u573a\uff0c\u5982\u6709\u9519\u8bef\u6216\u76f8\u5173\u4fb5\u6743\u8bf7\u8054\u7cfb\u6211\u4eec\u5220\u9664\uff0c\u8c22\u8c22\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

\u25b3\u8bfa\u548c\u8bfa\u5fb7\u7684GLP-1\u51cf\u80a5\u836f\u7247\uff0c\u76ee\u524d\u5c1a\u672a\u5728\u4efb\u4f55\u5730\u533a\u83b7\u51c6\u4f7f\u7528\u3002\u56fe\u7247\u6765\u6e90\uff1aNOVO NORDISK \u4e9a\u7279\u5170\u5927\u5730\u533a\u7684\u80a5\u80d6\u75c7\u533b\u5b66\u4e13\u5bb6\u3001\u7f8e\u56fd\u4e34\u5e8a\u5185\u5206\u6ccc\u5b66\u534f\u4f1a(American Association of Clinical Endocrinology)\u4f1a\u957f\u65af\u79d1\u7279\u30fb\u827e\u8428\u514b\u65af(Scott Isaacs)\u535a\u58eb\u8bf4\uff1a\u201c\u8bb8\u591a\u60a3\u8005\u5c1d\u8bd5\u8fc7\u4e0d\u540c\u7684\u836f\u7269\uff0c\u4f46\u8981\u4e48\u5bf9\u4ed6\u4eec\u65e0\u6548\uff0c\u8981\u4e48\u6709\u526f\u4f5c\u7528\uff0c\u4ed6\u4eec\u60f3\u5c1d\u8bd5\u4e00\u4e9b\u65b0\u4e1c\u897f\u3002\u201d\u4ed6\u79f0\uff1a\u201c\u6211\u8ba4\u4e3a\uff0c\u591a\u4e00\u4e2a\u53ef\u4f9b\u8f6c\u6362\u7684\u9009\u62e9\uff0c\u5bf9\u5f88\u591a\u4eba\u6765\u8bf4\u90fd\u4f1a\u6709\u5438\u5f15\u529b\u3002\u201d \u8bfa\u548c\u8bfa\u5fb7(Novo Nordisk)\u7684\u53f8\u7f8e\u683c\u9c81\u80bd(semaglutide)\u53e3\u670d\u836f\u6709\u671b\u6210\u4e3a\u9996\u6b3e\u4e13\u95e8\u83b7\u6279\u7528\u4e8e\u51cf\u80a5\u7684GLP-1\u53e3\u670d\u836f\u3002\u53f8\u7f8e\u683c\u9c81\u80bd\u662fWegovy\u548c\u7cd6\u5c3f\u75c5\u6cbb\u7597\u836f\u7269\u8bfa\u548c\u6cf0(Ozempic)\u7684\u4e3b\u8981\u6210\u5206\u3002\u8be5\u516c\u53f8\u5df2\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40(U.S. Food and Drug Administration, \u7b80\u79f0FDA)\u63d0\u4ea4\u7533\u8bf7\uff0c\u9884\u8ba1\u5ba1\u6279\u51b3\u5b9a\u5c06\u5728\u5e74\u5e95\u524d\u505a\u51fa\uff0c\u4ece\u800c\u4f7f\u8be5\u836f\u53ef\u80fd\u57282026\u5e74\u521d\u4e0a\u5e02\u3002 \u793c\u6765\u516c\u53f8(Eli Lilly)\u7684\u540c\u7c7b\u4ea7\u54c1\u542b\u6709\u4e00\u79cd\u65b0\u7684\u4e3b\u8981\u6210\u5206orforglipron\uff0c\u4f5c\u7528\u65b9\u5f0f\u4e0d\u540c\u4e8e\u5176\u6ce8\u5c04\u5242Zepbound\u7684\u4e3b\u8981\u6210\u5206\u66ff\u5c14\u6cca\u80bd(tirzepatide)\u3002Orforglipron\u662f\u4e00\u79cdGLP-1\u836f\u7269\uff0c\u53ef\u6a21\u62df\u4e00\u79cd\u80a0\u9053\u6fc0\u7d20\u6765\u5e2e\u52a9\u6291\u5236\u98df\u6b32\u3002\u4f46\u5b83\u4e0d\u50cfZepbound\u90a3\u6837\u540c\u65f6\u6a21\u62df\u7b2c\u4e8c\u79cd\u80a0\u9053\u6fc0\u7d20\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u7814\u7a76\u8868\u660e\u5b83\u7684\u6548\u679c\u4e0d\u5982\u6ce8\u5c04\u5242\u3002\u8be5\u516c\u53f8\u8ba1\u5212\u5728\u4eca\u5e74\u5e74\u5e95\u524d\u5411FDA\u7533\u8bf7\u6279\u51c6\u8be5\u836f\uff0c\u4ece\u800c\u53ef\u80fd\u57282026\u5e74\u7684\u67d0\u4e2a\u65f6\u5019\u4e0a\u5e02\u3002 \u5305\u62ec\u963f\u65af\u5229\u5eb7(AstraZeneca)\u548cStructure Therapeutics\u5728\u5185\u7684\u5176\u4ed6\u516c\u53f8\u4e5f\u5728\u5f00\u53d1\u6b64\u7c7b\u53e3\u670d\u836f\uff0c\u5982\u679c\u6d4b\u8bd5\u6210\u529f\uff0c\u53ef\u80fd\u4f1a\u5728\u51e0\u5e74\u540e\u4e0a\u5e02\u3002 \u4e0e\u6ce8\u5c04\u5242\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u65b0\u53e3\u670d\u836f\u53ef\u80fd\u9700\u8981\u6743\u8861\u5229\u5f0a\u3002\u7814\u7a76\u663e\u793a\uff0c\u670d\u7528\u53e3\u670d\u836f\u53ef\u80fd\u51cf\u91cd\u6548\u679c\u4e0d\u4f73\u3002\u800c\u4e14\u4e0e\u6ce8\u5c04\u5242\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u53e3\u670d\u836f\u53ef\u80fd\u4f1a\u5728\u66f4\u591a\u60a3\u8005\u4e2d\u5f15\u8d77\u6076\u5fc3\u7b49\u80a0\u80c3\u76f8\u5173\u526f\u4f5c\u7528\u3002\u533b\u751f\u548c\u5206\u6790\u5e08\u8868\u793a\uff0c\u8fd9\u4e9b\u53e3\u670d\u836f\u53ef\u80fd\u66f4\u9002\u5408\u9700\u8981\u51cf\u53bb\u8f83\u5c11\u4f53\u91cd\u7684\u4eba\uff0c\u800c\u91cd\u5ea6\u80a5\u80d6\u8005\u53ef\u80fd\u9700\u8981\u575a\u6301\u4f7f\u7528\u6ce8\u5c04\u5242\u3002 \u5373\u4f7f\u5b58\u5728\u5c40\u9650\u6027\uff0cGLP-1\u51cf\u80a5\u53e3\u670d\u836f\u7684\u5e02\u573a\u4e5f\u53ef\u80fd\u975e\u5e38\u5e9e\u5927\u3002Leerink Partners\u4e13\u6ce8\u4e8e\u533b\u7597\u5065\u5eb7\u6295\u8d44\u94f6\u884c\u4e1a\u52a1\uff0c\u8be5\u673a\u6784\u5206\u6790\u5e08\u5927\u536b\u30fb\u8d56\u8f9b\u683c(David Risinger)\u4f30\u8ba1\uff0c\u8fd9\u7c7b\u53e3\u670d\u836f\u6700\u7ec8\u53ef\u80fd\u5360\u636e\u6574\u4e2a\u5e02\u573a\u7ea625%\u7684\u4efd\u989d\u3002\u8d56\u8f9b\u683c\u8bf4\uff1a\u201c\u5b83\u4eec\u4ecd\u6709\u6f5c\u529b\u521b\u9020\u5de8\u989d\u9500\u552e\u989d\uff0c\u56e0\u4e3a\u6d88\u8d39\u8005\u5bf9\u53e3\u670d\u51cf\u80a5\u836f\u7684\u9700\u6c42\u5c06\u662f\u5de8\u5927\u7684\u3002\u201d \u636e\u5206\u6790\u516c\u53f8TD 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\u5373\u4f7f\u5b58\u5728\u5c40\u9650\u6027\uff0cGLP-1\u51cf\u80a5\u53e3\u670d\u836f\u7684\u5e02\u573a\u4e5f\u53ef\u80fd\u975e\u5e38\u5e9e\u5927\u3002Leerink Partners\u4e13\u6ce8\u4e8e\u533b\u7597\u5065\u5eb7\u6295\u8d44\u94f6\u884c\u4e1a\u52a1\uff0c\u8be5\u673a\u6784\u5206\u6790\u5e08\u5927\u536b\u30fb\u8d56\u8f9b\u683c(David Risinger)\u4f30\u8ba1\uff0c\u8fd9\u7c7b\u53e3\u670d\u836f\u6700\u7ec8\u53ef\u80fd\u5360\u636e\u6574\u4e2a\u5e02\u573a\u7ea625%\u7684\u4efd\u989d\u3002\u8d56\u8f9b\u683c\u8bf4\uff1a\u201c\u5b83\u4eec\u4ecd\u6709\u6f5c\u529b\u521b\u9020\u5de8\u989d\u9500\u552e\u989d\uff0c\u56e0\u4e3a\u6d88\u8d39\u8005\u5bf9\u53e3\u670d\u51cf\u80a5\u836f\u7684\u9700\u6c42\u5c06\u662f\u5de8\u5927\u7684\u3002\u201d \u636e\u5206\u6790\u516c\u53f8TD Cowen\u79f0\uff0c\u76ee\u524d\u8fd9\u6279\u6ce8\u5c04\u836f\u7269\uff08\u5305\u62ec\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff09\u9884\u8ba1\u4eca\u5e74\u5c06\u5728\u5168\u7403\u4ea7\u751f\u7ea6720\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002 TD Cowen\u7684\u5206\u6790\u5e08\u8fc8\u514b\u5c14\u30fb\u5185\u5fb7\u5c14\u79d1\u7ef4\u5947(Michael Nedelcovych)\u8868\u793a\uff0c\u8fd9\u4e9b\u516c\u53f8\u53ef\u80fd\u5fc5\u987b\u514b\u670d\u533b\u751f\u7684\u6000\u7591\u6001\u5ea6\u3002\u4ed6\u7684\u8c03\u67e5\u663e\u793a\uff0c\u533b\u751f\u666e\u904d\u8ba4\u4e3a\u6ce8\u5c04\u836f\u7269\u66f4\u6709\u6548\uff0c\u5e76\u4e14\u6ca1\u6709\u770b\u5230\u60a3\u8005\u5bf9\u53e3\u670d\u836f\u6709\u8feb\u5207\u9700\u6c42\u3002\u4f46\u4ed6\u8868\u793a\uff0c\u5982\u679c\u53e3\u670d\u836f\u5b9a\u4ef7\u8f83\u4f4e\uff0c\u4fdd\u9669\u8986\u76d6\u8303\u56f4\u53ef\u80fd\u4f1a\u66f4\u597d\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u9500\u552e\u3002 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\u201c\u4f60\u5c06\u4ee5\u4e00\u79cd\u4e0e\u6ce8\u5c04\u578bGLP-1\u975e\u5e38\u76f8\u4f3c\u7684\u65b9\u5f0f\uff0c\u83b7\u5f97\u51cf\u80a5\u3001\u8840\u7cd6\u63a7\u5236\u4ee5\u53ca\u6240\u6709\u8fd9\u4e9b\u771f\u6b63\u91cd\u8981\u7684\u4e8b\u60c5\uff0c\u201d \u793c\u6765\u5fc3\u810f\u4ee3\u8c22\u5065\u5eb7\u90e8\u95e8\u603b\u88c1\u80af\u5185\u65af\u30fb\u5361\u65af\u7279(Kenneth Custer)\u8bf4\u3002\u201c\u4f46\u73b0\u5728\u4f60\u4ee5\u53e3\u670d\u836f\u7684\u5f62\u5f0f\u83b7\u5f97\u5b83\uff0c\u8fd9\u79cd\u5f62\u5f0f\u53ef\u4ee5\u771f\u6b63\u5927\u89c4\u6a21\u63a8\u5e7f\uff0c\u5e76\u4e14\u6613\u4e8e\u60a3\u8005\u4f7f\u7528\u3002\u201d 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\u8bfa\u548c\u8bfa\u5fb7\u7684\u8fd9\u6b3e\u53e3\u670d\u836f\u8fd8\u5fc5\u987b\u7a7a\u8179\u670d\u7528\uff0c\u7136\u540e\u60a3\u8005\u9700\u8981\u7b49\u5f8530\u5206\u949f\u624d\u80fd\u8fdb\u98df\u3002\u4e00\u4e9b\u5206\u6790\u5e08\u8ba4\u4e3a\uff0c\u4e0e\u793c\u6765\u7684\u53e3\u670d\u836f\u76f8\u6bd4\uff0c\u8fd9\u662f\u4e00\u4e2a\u52a3\u52bf\uff0c\u540e\u8005\u6ca1\u6709\u8fd9\u6837\u7684\u9650\u5236\u3002 \u8bfa\u548c\u8bfa\u5fb7\u9996\u5e2d\u79d1\u5b66\u5b98\u9a6c\u4e01\u30fb\u970d\u5c14\u65af\u7279\u30fb\u5170\u683c(Martin Holst 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